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The corpus luteum (Latin for "yellow body"; : corpora lutea) is a temporary endocrine structure in female ovaries involved in the production of relatively high levels of progesterone, and moderate levels of estradiol, and inhibin A. (2025). 9780070960527, McGraw-Hill Ryerson. ISBN 9780070960527 It is the remains of the ovarian follicle that has released a mature ovum during a previous ovulation.
The corpus luteum is colored as a result of concentrating (including lutein) from the diet and secretes a moderate amount of estrogen that inhibits further release of gonadotropin-releasing hormone (GnRH) and thus secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). A new corpus luteum develops with each menstrual cycle.
The corpus luteum is typically very large relative to the size of the ovary; in humans, the size of the structure ranges from under 2 cm to 5 cm in diameter.
Its cells develop from the follicular cells surrounding the ovarian follicle. The follicular luteinize into small luteal cells (thecal-lutein cells) and follicular luteinize into large luteal cells (granulosal-lutein cells) forming the corpus luteum. Progesterone is synthesized from cholesterol by both the large and small luteal cells upon luteal maturation. Cholesterol-LDL complexes bind to receptors on the plasma membrane of luteal cells and are internalized. Cholesterol is released and stored within the cell as cholesterol ester. LDL is recycled for further cholesterol transport. Large luteal cells produce more progesterone due to uninhibited/basal levels of protein kinase A (PKA) activity within the cell. Small luteal cells have LH receptors that regulate PKA activity within the cell. PKA actively phosphorylates steroidogenic acute regulatory protein (StAR) and translocator protein to transport cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane.
The development of the corpus luteum is accompanied by an increase in the level of the steroidogenic enzyme P450scc that converts cholesterol to pregnenolone in the mitochondria. Pregnenolone is then converted to progesterone that is secreted out of the cell and into the blood stream. During the bovine estrous cycle, plasma levels of progesterone increase in parallel to the levels of P450scc and its electron donor adrenodoxin, indicating that progesterone secretion is a result of enhanced expression of P450scc in the corpus luteum.
The mitochondrial P450 system electron transport chain including adrenodoxin reductase and adrenodoxin has been shown to leak electrons leading to the formation of superoxide radical. Apparently to cope with the radicals produced by this system and by enhanced mitochondrial metabolism, the levels of antioxidant enzymes catalase and superoxide dismutase also increase in parallel with the enhanced steroidogenesis in the corpus luteum.
| [[androgen]]s, [[progesterone]] | |
| progesterone, [[estrogen]](majority), and [[inhibin A]][http://www.bioeng.auckland.ac.nz/physiome/ontologies/female_repro_system/cells.php The IUPS Physiome Project --> Female Reproductive System – Cells] Retrieved on Nov 9, 2009 |
Like the previous theca cells, the theca lutein cells lack the aromatase enzyme that is necessary to produce estrogen, so they can only perform steroidogenesis until formation of . The granulosa lutein cells do have aromatase, and use it to produce estrogens, using the androgens previously synthesized by the theca lutein cells, as the granulosa lutein cells in themselves do not have the 17α-hydroxylase or 17,20 lyase to produce androgens. Once the corpus luteum regresses the remnant is known as corpus albicans.
With cessation of progesterone release, the uterine lining (functional, inner layer of the endometrium) is expelled through the vagina (in mammals that go through a menstrual cycle). Across an estrous cycle, the functional layer regenerates to provide nourishing tissue for potential fertilisation and implantation.
Human chorionic gonadotropin signals the corpus luteum to continue progesterone secretion, thereby maintaining the thick lining (endometrium) of the uterus and providing an area rich in in which the zygote(s) can develop. From this point on, the corpus luteum is called the corpus luteum graviditatis.
The introduction of at this point causes the degeneration of the corpus luteum and the abortion of the fetus. However, in placental animals such as humans, the placenta eventually takes over progesterone production and the corpus luteum degrades into a corpus albicans without embryo/fetus loss.
Luteal support refers to the administration of medication (generally ) for the purpose of increasing the success of implantation and early embryogenesis, thereby complementing the function of the corpus luteum.
File:Order_of_changes_in_ovary.svg|Order of changes in ovary
File:Human Ovary with Fully Developed Corpus Luteum.jpg|Human ovary with fully developed corpus luteum
File:Luteinized follicular cyst.jpg|Luteinized follicular cyst. H&E stain.
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